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KMID : 0371319940460060937
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Journal of the Korean Surgical Society
1994 Volume.46 No. 6 p.937 ~ p.948
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Overweight Related to the Risk of Breast Cancer by Menopausal Status in Korea
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Joo Jae-Sik
Yoo Keun-Young
Shin Myung-Hee
Roh Dong-Young
Choi Kook-Jin
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Abstract
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The incidence of breast cancer has steadily increased through the years. The establishment of the cause of breast cancer plays an important role for the diagnosis, management and further, if possible, prevention of breast cancer. Many kinds of
risk factors have been known to the cause of breast cancer. We studied the role of obesity in relation to the risk of breast cancer through a case-control study in Korea. Included in the analysis were 162 women, identified as having a histologically-confirmed diagnosis of breast cancer in a hospital. The 150 hospital-controls were women free of any malignant neoplasms nor other systemic diseases. Randomly selected neighborhoods and friends of the patients (n=152) were also included as community controls in the analysis. Information on risk factors of breast cancer was collected by self-administered questionnaire, Statistical adjustment for potential confounders as well as a likelhood ratio test for trend was done by multivariate linear logistic regression model. Among postmenopausal women, risk of breast cancer increased significantly with increasing relative weight (relative risk for the highest category was 7.40 in maximal weight compared with hospital controls). Some associations between the risk of breast cancer and some obesity indices, i.e., current weight, weight around 20 years of age, lifetime maximal weight, current Quetlet’s index, age at maximum weight, were found in the multivariate and likelihood ratio for trend analysis. Particularlynoteworthy was that the association between obesity and breast cancer risk was related in postmenopausal women. Among premenopausal women, having their cancer diagnosed before the age of 48.5, higher Quetlet’s index was not associated with a cancer risk, whereas a positive trend of likelihood ratio was seen among postmenopausal women. Especially the risk of breast cancer was increased among postmenopausal women whose maximum weight developed after 55 years of age. There was no association between current height and breast cancer risk among post and premenopausal women. These results suggest that there might be etiologic distinctions between premenopausal and postmenopausal breast cancer.
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KEYWORD
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Breast cancer, Case-contral study, Obesity
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